학술논문
Cooperative Somatic Alterations in XPO1 and TNFAIP3(A20) Promote Immune Modulation and Tissue Infiltration in Primary Mediastinal B Cell Lymphoma
Document Type
Article
Author
Source
Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p2995-2995, 1p
Subject
Language
ISSN
00064971; 15280020
Abstract
Background: Primary Mediastinal B cell lymphoma (PMBCL) is an aggressive large B cell non-Hodgkin lymphoma typically presenting as a mass in the anterior mediastinum in early adulthood, disproportionately affecting females (2:1). Previous studies have identified constitutive activation of the NF-κB pathway and immune evasion as hallmark features of PMBCL. The master negative regulator of canonical NF-κB, TNFAIP3(A20), is inactivated in ~25-60% of PMBCL cases via disruptive mutations or deletions. Gains of the 2p16.1-15 locus ( REL, XPO1, BCL11A)are seen in ~40-75% of PMBCL cases. Interestingly, PMBCL cases with 2p16.1-15 gain/amplification display concomitant increases in XPO1expression but lack correlative increases in RELor BCL11A. In addition, XPO1mutations are seen in ~15-33% of PMBCL cases, with the most prevalent mutation (E571K) implicated in NF-KB activation. Despite the established occurrence of genetic events impacting XPO1and A20 in PMBCL, the cooperative potential of these alterations remains unexplored. Consequently, we conducted an extensive review of literature describing the PMBCL genomic landscape and utilized in vivo models to examine the combined potential of XPO1and A20 alterations to promote lymphomagenesis.