학술논문
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks
Document Type
Article
Author
Source
Genes & Development; 2021, Vol. 35 Issue: 5-6 p329-334, 6p
Subject
Language
ISSN
08909369; 15495477
Abstract
In this study, Sinturel et al. sought to show that the suprachiasmatic nucleus (SCN) synchronizes peripheral circadian oscillators. By using long-term bioluminescence recordings in freely moving mice, they show that the SCN is indeed required for maintaining synchrony between organs and that circadian oscillations persist in the livers of mice devoid of an SCN or oscillators in cells other than hepatocytes.