학술논문
A randomized controlled crossover trial of aspirin for fatigue in multiple sclerosis
Document Type
Article
Author
Source
Neurology (Ovid); April 2005, Vol. 64 Issue: 7 p1267-1269, 3p
Subject
Language
ISSN
00283878; 1526632X
Abstract
Pharmacotherapeutic options for multiple sclerosis (MS)-related fatigue are limited. Thirty patients were randomly assigned to aspirin (ASA) 1,300 mg/day or placebo in a double-blind crossover study. Results favored ASA for the main clinical outcomes: Modified Fatigue Impact Scale scores (p0.043) and treatment preference (p0.012). There were no significant adverse effects. The results warrant further study and support a role for ASA-influenced mechanisms, perhaps immunologic, in the generation of MS-related chronic fatigue.