부산대학교 도서관

The IgM-associated peripheral neuropathies (PN) are a heterogeneous group of disorders representing most paraproteinaemic neuropathy cases. They are associated with IgM MGUS or Waldenström Macroglobulinaemia. Establishing a causal link between a paraprotein and neuropathy can be challenging but is necessary to adopt an appropriate therapeutic approach. The most common type of IgM-PN is anti-MAG neuropathy, but half of cases are of other aetiology. Progressive functional impairment is an indication for treatment, even when the underlying disorder is IgM MGUS, involving either rituximab monotherapy or combination chemotherapy to achieve clinical stabilisation.