학술논문
Discordance between T-Cell Receptor Expression and Effector Function in Mice Infected with Histoplasma capsulatum
Document Type
Article
Source
Infection and Immunity; March 2002, Vol. 70 Issue: 3 p1648-1652, 5p
Subject
Language
ISSN
00199567; 10985522
Abstract
ABSTRACTVβ10+and Vβ14+T cells were selectively increased 7 to 14 days following infection in the lungs of naive mice infected with Histoplasma capsulatum. Following secondary challenge of immune mice, Vβ1+and Vβ8.1+cells were sporadically increased. Elimination of Vβ10+and Vβ14+cells from naive mice did not alter the course of infection over a period of 21 days. Thus, overexpression of Vβ families does not necessarily signify a key role in host defense.