학술논문
Human Immunodeficiency Virus/AIDS, Human Papillomavirus, and Anal Cancer
Document Type
Article
Source
Surgical Oncology Clinics of North America; 20240101, Issue: Preprints
Subject
Language
ISSN
10553207
Abstract
Anal cancer is an increasingly common non–AIDS-defining cancer among individuals infected with the human immunodeficiency virus (HIV). It is associated with human papillomavirus (HPV). HPV16 is the most common genotype detected in anal cancers. The HPV types detected in anal cancer are included in the 9-valent vaccine. HPV vaccines have demonstrated efficacy in reducing anal precancerous lesions in HIV-infected individuals. Standard treatment has been fluorouracil and mitomycin (or cisplatin) plus radiation. Continued studies are needed to test new treatment strategies in HIV-infected patients with anal cancer to determine which treatment protocols provide the best therapeutic index.