학술논문
Genetic variation in the KCNMA1 potassium channel α subunit as risk factor for severe essential hypertension and myocardial infarction
Document Type
Article
Author
Source
Journal of Hypertension; November 2008, Vol. 26 Issue: 11 p2147-2153, 7p
Subject
Language
ISSN
02636352; 14735598
Abstract
The large conductance Ca2-dependent potassium channel plays a critical role in the control of vascular tone, coupling local increases in intracellular Ca2to membrane hyperpolarization and vascular relaxation. It also impacts blood pressure by modulating the renin–angiotensin–aldosterone system. Previous studies have shown that a polymorphism in the β1regulatory subunit of the Ca2-dependent potassium channel modulates the risk of diastolic hypertension in humans.