학술논문
Association Between Genetic Variants and the Risk of Nivolumab-Induced Immune-Related Adverse Events
Document Type
Article
Author
Source
Pharmacogenomics; November 2022, Vol. 23 Issue: 16 p887-901, 15p
Subject
Language
ISSN
14622416; 17448042
Abstract
Aim:We sought to identify the variants that could predict the risk of nivolumab-induced immune-related adverse events (irAEs) in patients with cancer. Patients & methods:We enrolled 622 Japanese patients and carried out a genome-wide association study. The associations for 507 single nucleotide polymorphisms (SNPs) showing p < 0.001 were further investigated using an independent cohort. Results:In the combined analysis, possible associations were found for a total of 90 SNPs. Although no SNPs were identified to be significantly associated with nivolumab-induced irAEs, the SNP most strongly associated with nivolumab-induced irAEs was rs469490. Conclusion:This study is an important hypothesis-generating study to guide future studies in larger and/or other ethnic cohorts.