학술논문
Murine monoclonal antibodies to the myelin-associated glycoprotein react with large granular lymphocytes of human blood.
Document Type
Article
Author
Source
Proceedings of the National Academy of Sciences of the United States of America; January 1985, Vol. 82 Issue: 2 p552-555, 4p
Subject
Language
ISSN
00278424; 10916490
Abstract
Monoclonal antibodies prepared to human myelin-associated glycoprotein were shown to react with a population of human peripheral blood mononuclear cells. The population is similar to the large granular lymphocytes or natural killer cells defined by antibody Leu 7 (also called HNK-1). The population also includes cells exhibiting the Leu 2 marker for suppressor/cytotoxic T cells. The results indicate a shared antigenicity between the nervous system and the immune system and may be relevant to the pathogenesis of demyelinating diseases.