학술논문
Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial
Document Type
Article
Author
Mitchell, Peter J; Yan, Bernard; Churilov, Leonid; Dowling, Richard J; Bush, Steven J; Bivard, Andrew; Huo, Xiao Chuan; Wang, Guoqing; Zhang, Shi Yong; Ton, Mai Duy; Cordato, Dennis J; Kleinig, Timothy J; Ma, Henry; Chandra, Ronil V; Brown, Helen; Campbell, Bruce C V; Cheung, Andrew K; Steinfort, Brendan; Scroop, Rebecca; Redmond, Kendal; Miteff, Ferdinand; Liu, Yan; Duc, Dang Phuc; Rice, Hal; Parsons, Mark W; Wu, Teddy Y; Nguyen, Huy-Thang; Donnan, Geoffrey A; Miao, Zhong Rong; Davis, Stephen M; Desmond, Patricia; Yassi, Nawaf; Zhao, Henry; Williams, Cameron; Alemseged, Fana; Ng, Felix C; Yogendrakumar, Vignan; Bailey, Peter; De Villiers, Laetitia; Phan, Thanh; Thirugnanachandran, Tharani; Chong, Winston; Asadi, Hamed; Slater, Lee Anne; Manning, Nathan; Wenderoth, Jason; McDougall, Alan; Williams, Cameron; Cappelen-Smith, Cecilia; Whitley, Justin; Edwards, Leon; Esperon, Carlos Garcia; Spratt, Neil; Pepper, Elizabeth; Levi, Chris; Faulder, Ken; Harrington, Timothy; Krause, Martin; Waters, Michael; Fink, John; Ma, Gaoting; Shen, Xiangpeng; Song, Xiangkong; Gao, Yonglei; Guangxian, Nam; Guo, Zaiyu; Zhang, Heliang; Han, Hongxing; Wang, Hao; Liao, Geng; Zhang, Zhenyu; Li, Chaomao; Yang, Zhi; Cai, Chuwei; Huang, Chuming; Hong, Yifan
Source
The Lancet; July 2022, Vol. 400 Issue: 10346 p116-125, 10p
Subject
Language
ISSN
01406736; 1474547X
Abstract
The benefit of combined treatment with intravenous thrombolysis before endovascular thrombectomy in patients with acute ischaemic stroke caused by large vessel occlusion remains unclear. We hypothesised that the clinical outcomes of patients with stroke with large vessel occlusion treated with direct endovascular thrombectomy within 4·5 h would be non-inferior compared with the outcomes of those treated with standard bridging therapy (intravenous thrombolysis before endovascular thrombectomy).