학술논문
Effects of MDR1and OPRM1Genetic Polymorphisms on the Pharmacodynamics of Propofol–Remifentanil TIVA in Pediatrics
Document Type
Article
Author
Source
Pharmacogenomics; April 2023, Vol. 24 Issue: 5 p247-259, 13p
Subject
Language
ISSN
14622416; 17448042
Abstract
Aims:To investigate the roles of MDR1(1236C>T, 2677G>T/A, and 3435C>T) and OPRM1(118A>G) gene polymorphisms on the anesthetic and adverse effects of propofol–remifentanil total intravenous anesthesia in pediatric surgery. Materials & methods:The genotypes were identified through Sanger sequencing. The clinical data including hemodynamics on anesthesia, postanesthesia pain and sedation score and the occurrence of adverse effects were recorded and compared against the genetic data. Results:A total of 72 pediatric patients undergoing surgery were recruited. A weak to no association was found between the genetic polymorphisms of MDR1and OPRM1and the anesthetic and adverse effects of propofol–remifentanil. Conclusion:Genetic polymorphisms in OPRM1, but not in MDR1, gene polymorphism, demonstrated plausible association with the effects of propofol–remifentanil.