학술논문
The role of CD8+T-cell clones in immune thrombocytopenia
Document Type
Article
Author
Malik, Amna; Sayed, Anwar A.; Han, Panpan; Tan, Michelle M. H.; Watt, Eleanor; Constantinescu-Bercu, Adela; Cocker, Alexander T. H.; Khoder, Ahmad; Saputil, Rocel; Thorley, Emma; Teklemichael, Ariam; Ding, Yunchuan; Hart, Alice; Zhang, Haiyu; Mitchell, Wayne A.; Imami, Nesrina; Crawley, James T. B.; Salles-Crawley, Isabelle; Bussel, James B.; Zehnder, James L.; Adams, Stuart; Zhang, Bing M.; Cooper, Nichola
Source
Blood; 20230101, Issue: Preprints
Subject
Language
ISSN
00064971; 15280020
Abstract
•Patients with chronic ITP had clonal expansions of disease-associated TEMRA CD8+T cells.•CD8+T cells bind to platelets and cause their activation and apoptosis, defining an antibody-independent mechanism of platelet destruction.