학술논문
l-Amino acid oxidase isolated from Calloselasma rhodostomasnake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines
Document Type
Article
Author
Source
Revista Brasileira de Hematologia e Hemoterapia; April-June 2016, Vol. 38 Issue: 2 p128-134, 7p
Subject
Language
ISSN
15168484; 18060870
Abstract
Myeloproliferative neoplasms are Philadelphia chromosome-negative diseases characterized by hyperproliferation of mature myeloid cells, associated or not with the Janus kinase 2 tyrosine kinase mutation, JAK2V617F. As there is no curative therapy, researchers have been investigating new drugs to treat myeloproliferative neoplasms, including l-amino acid oxidase from Calloselasma rhodostomasnake venom (CR-LAAO), which is a toxin capable of eliciting apoptosis in several tumor cell lines.