학술논문
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
Document Type
Article
Author
Folegatti, Pedro M; Ewer, Katie J; Aley, Parvinder K; Angus, Brian; Becker, Stephan; Belij-Rammerstorfer, Sandra; Bellamy, Duncan; Bibi, Sagida; Bittaye, Mustapha; Clutterbuck, Elizabeth A; Dold, Christina; Faust, Saul N; Finn, Adam; Flaxman, Amy L; Hallis, Bassam; Heath, Paul; Jenkin, Daniel; Lazarus, Rajeka; Makinson, Rebecca; Minassian, Angela M; Pollock, Katrina M; Ramasamy, Maheshi; Robinson, Hannah; Snape, Matthew; Tarrant, Richard; Voysey, Merryn; Green, Catherine; Douglas, Alexander D; Hill, Adrian V S; Lambe, Teresa; Gilbert, Sarah C; Pollard, Andrew J; Aboagye, Jeremy; Adams, Kelly; Ali, Aabidah; Allen, Elizabeth; Allison, Jennifer L.; Anslow, Rachel; Arbe-Barnes, Edward H.; Babbage, Gavin; Baillie, Kenneth; Baker, Megan; Baker, Natalie; Baker, Philip; Baleanu, Ioana; Ballaminut, Juliana; Barnes, Eleanor; Barrett, Jordan; Bates, Louise; Batten, Alexander; Beadon, Kirsten; Beckley, Rebecca; Berrie, Eleanor; Berry, Lisa; Beveridge, Amy; Bewley, Kevin R.; Bijker, Else Margreet; Bingham, Tracey; Blackwell, Luke; Blundell, Caitlin L.; Bolam, Emma; Boland, Elena; Borthwick, Nicola; Bower, Thomas; Boyd, Amy; Brenner, Tanja; Bright, Philip D.; Brown-O'Sullivan, Charlie; Brunt, Emily; Burbage, Jamie; Burge, Sharon; Buttigieg, Karen R.; Byard, Nicholas; Cabera Puig, Ingrid; Calvert, Anna; Camara, Susana; Cao, Michelangelo; Cappuccini, Federica; Carr, Melanie; Carroll, Miles W.; Carter, Victoria; Cathie, Katrina; Challis, Ruth J.; Charlton, Sue; Chelysheva, Irina; Cho, Jee-Sun; Cicconi, Paola; Cifuentes, Liliana; Clark, Helen; Clark, Elizabeth; Cole, Tom; Colin-Jones, Rachel; Conlon, Christopher P.; Cook, Aislinn; Coombes, Naomi S.; Cooper, Rachel; Cosgrove, Catherine A.; Coy, Karen; Crocker, Wendy E.M.; Cunningham, Christina J.; Damratoski, Brad E.; Dando, Lynne; Datoo, Mehreen S.; Davies, Hannah; De Graaf, Hans; Demissie, Tesfaye; Di Maso, Claudio; Dietrich, Isabelle; Dong, Tao; Donnellan, Francesca R.; Douglas, Naomi; Downing, Charlotte; Drake, Jonathan; Drake-Brockman, Rachael; Drury, Ruth Elizabeth; Dunachie, Susanna Jane; Edwards, Nick J.; Edwards, Frances D.L.; Edwards, Chris J.; Elias, Sean C.; Elmore, Michael J.; Emary, Katherine R.W.; English, Marcus Rex; Fagerbrink, Susanne; Felle, Sally; Feng, Shuo; Field, Samantha; Fixmer, Carine; Fletcher, Clare; Ford, Karen J.; Fowler, Jamie; Fox, Polly; Francis, Emma; Frater, John; Furze, Julie; Fuskova, Michelle; Galiza, Eva; Gbesemete, Diane; Gilbride, Ciaran; Godwin, Kerry; Gorini, Giacomo; Goulston, Lyndsey; Grabau, Caroline; Gracie, Lara; Gray, Zoe; Guthrie, Lucy Belle; Hackett, Mark; Halwe, Sandro; Hamilton, Elizabeth; Hamlyn, Joseph; Hanumunthadu, Brama; Harding, Irasha; Harris, Stephanie A.; Harris, Andrew; Harrison, Daisy; Harrison, Clare; Hart, Thomas C.; Haskell, Louise; Hawkins, Sophia; Head, Ian; Henry, John Aaron; Hill, Jennifer; Hodgson, Susanne H.C.; Hou, Mimi M.; Howe, Elizabeth; Howell, Nicola; Hutlin, Cecilia; Ikram, Sabina; Isitt, Catherine; Iveson, Poppy; Jackson, Susan; Jackson, Frederic; James, Sir William; Jenkins, Megan; Jones, Elizabeth; Jones, Kathryn; Jones, Christine E.; Jones, Bryony; Kailath, Reshma; Karampatsas, Konstantinos; Keen, Jade; Kelly, Sarah; Kelly, Dearbhla; Kerr, David; Kerridge, Simon; Khan, Liaquat; Khan, Uzma; Killen, Annabel; Kinch, Jasmin; King, Thomas B.; King, Lloyd; King, Jade; Kingham-Page, Lucy; Klenerman, Paul; Knapper, Francesca; Knight, Julian C.; Knott, Daniel; Koleva, Stanislava; Kupke, Alexandra; Larkworthy, Colin W.; Larwood, Jessica P.J.; Laskey, Anna; Lawrie, Alison M.; Lee, Arlene; Ngan Lee, Kim Yee; Lees, Emily A; Legge, Helen; Lelliott, Alice; Lemm, Nana-Marie; Lias, Amelia M.; Linder, Aline; Lipworth, Samuel; Liu, Xinxue; Liu, Shuchang; Lopez Ramon, Raquel; Lwin, May; Mabesa, Francesca; Madhavan, Meera; Mallett, Garry; Mansatta, Kushal; Marcal, Ines; Marinou, Spyridoula; Marlow, Emma; Marshall, Julia L.; Martin, Jane; McEwan, Joanne; McInroy, Lorna; Meddaugh, Gretchen; Mentzer, Alexander J.; Mirtorabi, Neginsadat; Moore, Maria; Moran, Edward; Morey, Ella; Morgan, Victoria; Morris, Susan Jane; Morrison, Hazel; Morshead, Gertraud; Morter, Richard; Mujadidi, Yama F.; Muller, Jilly; Munera-Huertas, Tatiana; Munro, Claire; Munro, Alasdair; Murphy, Sarah; Munster, Vincent J.; Mweu, Philomena; Noé, Andrés; Nugent, Fay L.; Nuthall, Elizabeth; O'Brien, Katie; O'Connor, Daniel; Oguti, Blanché; Oliver, Jennifer L.; Oliveira, Catarina; O'Reilly, Peter John; Osborn, Mairead; Osborne, Piper; Owen, Cathy; Owens, Daniel; Owino, Nelly; Pacurar, Mihaela; Parker, Kaye; Parracho, Helena; Patrick-Smith, Maia; Payne, Victoria; Pearce, Jennifer; Peng, Yanchun; Peralta Alvarez, Marco Polo; Perring, James; Pfafferott, Katja; Pipini, Dimitra; Plested, Emma; Pluess-Hall, Helen; Pollock, Katrina; Poulton, Ian; Presland, Laura; Provstgaard-Morys, Samuel; Pulido, David; Radia, Kajal; Ramos Lopez, Fernando; Rand, Jade; Ratcliffe, Helen; Rawlinson, Thomas; Rhead, Sarah; Riddell, Amy; Ritchie, Adam John; Roberts, Hannah; Robson, Joanna; Roche, Sophie; Rohde, Cornelius; Rollier, Christine S.; Romani, Rossana; Rudiansyah, Indra; Saich, Stephen; Sajjad, Sara; Salvador, Stephannie; Sanchez Riera, Lidia; Sanders, Helen; Sanders, Katherine; Sapaun, Shari; Sayce, Chloe; Schofield, Ella; Screaton, Gavin; Selby, Beatrice; Semple, Calum; Sharpe, Hannah R.; Shaik, Imam; Shea, Adam; Shelton, Holly; Silk, Sarah; Silva-Reyes, Laura; Skelly, Donal T.; Smee, Heather; Smith, Catherine C.; Smith, David J.; Song, Rinn; Spencer, Alexandra J.; Stafford, Elizabeth; Steele, Amy; Stefanova, Elena; Stockdale, Lisa; Szigeti, Anna; Tahiri-Alaoui, Abdessamad; Tait, Moira; Talbot, Helen; Tanner, Rachel; Taylor, Iona Jennifer; Taylor, Victoria; Te Water Naude, Rebecca; Thakur, Nazia; Themistocleous, Yrene; Themistocleous, Andreas; Thomas, Merin; Thomas, Tonia M.; Thompson, Amber; Thomson-Hill, Samantha; Tomlins, Jennifer; Tonks, Susan; Towner, James; Tran, Nguyen; Tree, Julia A.; Truby, Adam; Turkentine, Kate; Turner, Cheryl; Turner, Nicola; Turner, Sally; Tuthill, Toby; Ulaszewska, Marta; Varughese, Rachel; Van Doremalen, Neeltje; Veighey, Kristin; Verheul, Marije K.; Vichos, Iason; Vitale, Elia; Walker, Laura; Watson, Marion E.E.; Welham, Benjamin; Wheat, Julie; White, Caroline; White, Rachel; Worth, Andrew T.; Wright, Danny; Wright, Suzie; Yao, Xin Li; Yau, Yasmine
Source
The Lancet; August 2020, Vol. 396 Issue: 10249 p467-478, 12p
Subject
Language
ISSN
01406736; 1474547X
Abstract
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might be curtailed by vaccination. We assessed the safety, reactogenicity, and immunogenicity of a viral vectored coronavirus vaccine that expresses the spike protein of SARS-CoV-2.