학술논문
Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial
Document Type
Article
Author
Tofte, Nete; Lindhardt, Morten; Adamova, Katarina; Bakker, Stephan J L; Beige, Joachim; Beulens, Joline W J; Birkenfeld, Andreas L; Currie, Gemma; Delles, Christian; Dimos, Ingo; Francová, Lidmila; Frimodt-Møller, Marie; Girman, Peter; Göke, Rüdiger; Havrdova, Tereza; Heerspink, Hiddo J L; Kooy, Adriaan; Laverman, Gozewijn D; Mischak, Harald; Navis, Gerjan; Nijpels, Giel; Noutsou, Marina; Ortiz, Alberto; Parvanova, Aneliya; Persson, Frederik; Petrie, John R; Ruggenenti, Piero L; Rutters, Femke; Rychlík, Ivan; Siwy, Justyna; Spasovski, Goce; Speeckaert, Marijn; Trillini, Matias; Zürbig, Petra; von der Leyen, Heiko; Rossing, Peter; Zimmermann, Silke; Rädisch, Brit; Hävemeier, Anika; Busmann, Annette; Wittkop, Ulrike; Neuhaus, Barbara; Ax-Smolarski, Regina; Zieglschmid, Veit; Bollweber, Eva; Wölk, Heidrun; Curovic, Viktor R.; Tougaard, Ninna H.; Eickhoff, Mie K.; Pilemann-Lyberg, Sascha; Winther, Signe A.; Rosenlund, Signe V.; Hansen, Tine W.; von Scholten, Bernt J.; Hansen, Christian S.; Zobel, Emilie H.; Laursen, Jens C.; Theilade, Simone; Jelstrup, Lone; Juhl, Tina R.; Riis, Dorthe; Hermann, Jessie A.; Lundgaard, Anne G.; Halkjær, Maja L.D.; Aabo, Lene; Frost Lerche, Therese; Lajer, Maria; Stefansen, Rikke J.; Campbell, Maria A.; Durban, Annika; Raad, Julia; Prigge, Michael; Schiemann, Marco; Wilson, Robbie; Kean, Sharon; Douglas, Elizabeth; Surtees, Pamela; Gant, Christina; Yeung, Stanley M.H.; Hagedoorn, Ilse; Flynn, Joanne; Galloway, Joe; Brooksbank, Katriona; Aparicio, Carolina; Iliev, Ilian P.; Nones, Francesco; Lo Bue, Francesca; Melacini, Daniela; Cugini, Daniela; Prandini, Silvia; Lecchi, Verusca; Yakymchuk, Svitlana; Gherardi, Giulia; Villa, Alessandro; Villa, Davide; Gaspari, Flavio; Cannata, Antonio N.; Ferrari, Silvia; Stucchi, Nadia; Albrechtová, Šárka; Eldeik, Elina; Amanaki, Renata; Fernandez-Fernandez, Beatriz; Sanchez-Rodriguez, Jinny; Vázquez, Clotilde; Sanz, Ana B.; Sanchez-Niño, Maria D.; Ramos, Adrian M.; Gonzalo, Maria Á.; Schmidt, Ulrike; Selim, Gjulsen; Gjorgovski, Tatjana; Stratrova, Slavica S.; Stojceva-Taneva, Olivera; Schutten-Westerneng, Petra; Wierbos, Brenda; Huvers, Frank; De Bruin, Anneke K.; Lapauw, Bruno; de Man, Elsie; Rokegem, Kelly; Inion, Sabien; Kreutzmann, Kristin; Dewettinck, Isabelle; Boukens-de Graaf, Caroline; Clerc-de Jong, Ferrina; Entius, Jannet; Nannings, Marian; van Steenderen, Suzy; Petry, Friedrich W.; Kilic, Ceyda
Source
The Lancet Diabetes & Endocrinology; April 2020, Vol. 8 Issue: 4 p301-312, 12p
Subject
Language
ISSN
22138587; 22138595
Abstract
Microalbuminuria is an early sign of kidney disease in people with diabetes and indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic risk classifier (CKD273) score was associated with development of microalbuminuria and whether progression to microalbuminuria could be prevented with the mineralocorticoid receptor antagonist spironolactone.