부산대학교 도서관

A unique prenylated bicarbazole alkaloid, clausanisumine (1), and two biogenetically related known monomer carbazole alkaloids, mukonal (2) and 3-methylcarbazole (3), were isolated from the fruits of Clausena anisum-olens. Clausanisumine (1) was an uncommon prenylated bicarbazole alkaloid, possessing an unprecedented carbon skeleton, which was composed of a simple carbazole alkaloid and a prenylated carbazole alkaloid. The chemical structure of 1was established by a combination of comprehensive spectral methods. A plausible biosynthetic pathway of 1was also proposed. Additionally, the potential anti-HIV activities of all isolates 1–3in vitrowere evaluated. Compound 1exhibited remarkable anti-HIV-1 reverse transcriptase effects showing an EC50value of 18.58 nM. The discovery of the prenylated bicarbazole alkaloid from C. anisum-olenswith notable anti-HIV activity would be meaningful to discovering and developing new anti-HIV drugs.