학술논문
Efficacy and safety of ligelizumab in adults and adolescents with chronic spontaneous urticaria: results of two phase 3 randomised controlled trials
Document Type
Article
Author
Maurer, Marcus; Ensina, Luis Felipe; Gimenez-Arnau, Ana Maria; Sussman, Gordon; Hide, Michihiro; Saini, Sarbjit; Grattan, Clive; Fomina, Daria; Rigopoulos, Dimitrios; Berard, Frederic; Canonica, Giorgio Walter; Rockmann, Heike; Irani, Carla; Szepietowski, Jacek C; Leflein, Jeffrey; Bernstein, Jonathan A; Peter, Jonny G; Kulthanan, Kanokvalai; Godse, Kiran; Ardusso, Ledit; Ukhanova, Olga; Staubach, Petra; Sinclair, Rodney; Gogate, Shaila; Thomsen, Simon Francis; Tanus, Tonny; Ye, Young Min; Burciu, Alis; Barve, Avantika; Modi, Darshna; Scosyrev, Emil; Hua, Eva; Letzelter, Kerstin; Varanasi, Vineeth; Patekar, Manmath; Severin, Thomas; Rosana, Agondi; Ahmed, Al Waily; Fabio, Almerigogna; Miguel Angel Tejedor, Alonso; Alfred, Ammoury; Eng Kim, Anne Goh; Robert, Anolik; Ledit, Ardusso; Petr, Arenberger; Nandini, AS; Mohammad, Asefi; Natalia, Astafieva; Anil, Badhwar; Esther Serra, Baldrich; Christine, Bangert; Annick, Barbaud; Zsuzsanna, Bata-Csorgo; Andrea, Bauer; Frederic, Berard; Beata, Bergler-Czop; Gary D, Berman; Jonathan, Bernstein; Subhash Chandra, Bharija; Ramesh M, Bhat; Isabelle, Boccon-Gibod; Ivan, Botev; Knut, Brockow; Philipp, Buck; Paula, Busse; Regis, Campos; Giorgio Walter, Canonica; Irani, Carla; Julia Maria Del, Carmen; Jaime Del, Carpio; Mamatha, Chadalavada; Yoon-Seok, Chang; Amarjit, Cheema; Yi Hsing, Chen; Yuko, Chinuki; Soyun, Cho; Jeong-Hee, Choi; Chia-Yu, Chu; Ronit, Confino; Jonathan, Corren; Roberta, Criado; Claudia De La, Cruz; David M, Cypcar; Pramila, Daftary; Inna, Danilycheva; Kenneth, Dawes; Michelle Joy, De Vera; James, Deangelo; Stefano, Del Giacco; Diana, Deleanu; John, Delgado; Richard, DeMera; Mohamed, Denguezli; Heinrich, Dickel; Le Huu, Doanh; Sinan, Dogan; Marie Sylvie, Doutre; Anne Sophie, Dupond; Anton, Edin; Kent, EDWARD; Swarna, Ekanayake-Bohling; Daniel, Elbirt; David, Elkayam; Anne, Ellis; Shaunagh, Emanuel; Alexander, Emeliyanov; Burhan, Engin; Luis Felipe, Ensina; Ignacio Antepara, Ercoreca; Safiye, Ergun; Jose Luis Lopez, Estebaranz; Rustem, Fassakhov; Daria, Fomina; Linda, Ford; Mariangela, Francomano; Todd, Funkhouser; Remi, Gagnon; Ricardo, Galimberti; Cesar Alberto, Galvan Calle; Clovis, Galvao; Gabriel, Gattolin; Pierre-Dominique, Ghislain; Ana Maria, Gimenez Arnau; Elliot, Ginchansky; Francoise, Giordano-Labadie; Stanislav, Givirovsky; Kiran, Godse; Shaila, Gogate; Alan, Goldsobel; Francisca, Gomez; Rene Maximiliano, Gomez; Erika, Gonzalez; Paula Ribo, Gonzalez; Dimitar, Gospodinov; Clive, Grattan; Martine, Grosber; Gary, Gross; Francisco Jose Gomez, Guimera Martin-Neda; Rolland, Gyulai; Svetlana, Hadvabova; Suzana Ljubojevic, Hadzavdic; Hadi, Hamam; Daniela, Hasicova; Koremasa, Hayama; Pravin, Hissaria; Anna, Hjerppe; Ivan, Hlinka; Moises Labrador, Horrillo; Connie, Hsu; Yu-Huei, Huang; Iftikhar, Hussain; Atsuyuki, Igarashi; Beata, IMKO-WALCZUK; Huseyin Serhat, Inaloz; Rossella, Intravaia; Neal, Jain; Sanjeev, Jain; Sanjeev, Jain; Thilo, Jakob; Ruth Cerino, Javier; Antonio, João; Luiza Marek, Jozefowicz; Chang-Gyu, Jung; Martin, Kaatz; Nida, Kacar; Henry, Kanarek; Iva, Karlova; Alexander, Kastanayan; Jana, Kazandjieva; Johannes, Kern; Aharon, Kessel; Neena, Khanna; HeeJoo, Kim; Nancy, Kim; Sang-Ha, Kim; Tae-bum, Kim; Kulli, Kingo; Andreas, Kleinheinz; Janka, Komova; Evangelia, Kompoti; Tomas, Kopal; Peter, Kozub; Dorota, Krasowska; Beata, Krecisz; Burkhard, Kreft; Satsuki, Kubota; Hitoshi, Kudo; Teja, Kulkarni; Kanokvalai, Kulthanan; Akihiro, Kume; Maciej, Kupczyk; Edward, Lain; Bobby, Lanier; Hilde, Lapeere; Griselle Ortiz, Lasanta; Svetlana, Lazareva; Laura, Lazzeri; Dennis, Ledford; Donghun, Lee; Haur Yueh, Lee; Jeffrey, Leflein; Nicolas, Leitz; Nancy, Levin; Hermenio, Lima; Undine, Lippert; Brian, Lipson; Paula, Luna; Gabriel, Magarinos; Satyaprakash, Mahajan; Michail, Makris; Alejandro, Malbran; Ahmed Manjra, Manjra; Michael, Manning; Maria, Manrique; Adriana, Marcipar; Mariano, Marini; Veronique Del, Marmol; Jorge, Maspero; Tomoko, Matsuda; Jonathan, Matz; Marcus, Maurer; Wendy, McFalda; Anne, Mclaughlin; Iris, Medina; Rajesh Dutt, Mehta; Stephan, Meller; Steven, MELTZER; Raisa, Meshkova; Dorin, Mihalache; Francisco Javier, Miquel; Mourad, Mokni; J, Molhoek; Efrain, Montano; Sabine, Mueller; Javier Pedraz, Munoz; Toshikazu, Nagakura; Joanna, Narbutt; Ignasi Figueras, Nart; Ma. Lourdes M, Nebrida-Idea; Trong Hao, Nguyen; Johannes, Niesmann; Violeta Zaragoza, Ninet; Hiromitsu, Noguchi; Yuko Chinuki, Nomura; Roman, Nowicki; Tokuya, Omi; Robert, Onder; Ivan, Orojan; Francisco Javier, Ortiz de Frutos; Kim, Papp; Claudio, Parisi; Chun Wook, Park; Heungwoo, Park; Jungwon, Park; Young Min, Park; Viviana, Parra; Thierry, Passeron; Justine, Pasteur; Shivakumar, Patil; Vergil, Patrascu; Sylvia, Pauser; Anna Wojas, Pelc; Jonathan Grant, Peter; Wolfgang, Pfuetzner; Nicola, Pimpinelli; Andreas, Pinter; Cristian, Pizarro; Karel, Pizinger; Jarmila, Plutinska; Todor, Popov; Veronika, Popova; Marta Ferrer, Puga; Lara Ferrandiz, Pulido; Anca, Purcaru; Ulrike, Raap; Anna, Rajchel; John, Ramey; Ma Deanna Santos, Ramiscal; German Dario, Ramon; Syed, Rehman; Adam, Reich; Norbert, Reider; Krista, Ress; Dimitrios, Rigopoulos; Enrique, Rivas; Heike, Rockmann; Pierre-Paul, Roquet-Gravy; Menachem, Rottem; Vermen Verallo, Rowell; Franziska, Rueff; Juan Alberto Ruano, Ruiz; Juan, Russo; Ronald, Saff; Sarbjit, Saini; Maria, Salazar; Juan Francisco Silvestre, Salvador; Jorge, Sanchez; Florica, Sandru; Mark, Scarupa; Knut, Schaekel; Sibylle, Schliemann; Rik, Schrijvers; Beate, Schwarz; Andreas, Schwinn; Sudhir, Sekhsaria; Nilgun, Senturk; Seong Jun, Seo; Mercedes Rodriguez, Serna; Faradiba, Serpa; Paul A, Shapero; Eriko, Shinkawa; Jan-Christoph, Simon; Rodney, Sinclair; Ralfi, Singer; Dareen D, Siri; Karl, Sitz; Adam, Smialowski; Andrew, Smith; Morten, Soerensen; Wiebke, Sondermann; Haejun, Song; Dmitrii, Sonin; Weily, Soong; Daniel, Soteres; Maria, Staevska-Kotasheva; Petra, Staubach-Renz; Nisha Su Yien, Subash; Gordon, Sussman; Ake Svensson, Svensson; Ekaterini, Syrigou; Andrea, Szegedi; Jacek, Szepietowski; Shunsuke, Takahagi; Yuval, Tal; Neetu, Talreja; Wooi Chiang, Tan; Ricardo, Tan; Jyh Jong, Tang; Tonny, Tanus; Martha, Tarpay; Shang Ian, Tee; Craig, Teller; Florence, Tetart; Aurelie Du, Thanh; Suganthi, Thevarajah; Simon Francis, Thomsen; Carl, Thornblade; Milan, Tjioe; Alberto, Tolcachier; Celeste, Tolentino; Athanasios, Tsianakas; Ilia, Tsingov; Hamida, Turki; Olga, Ukhanova; Jens, Ulrich; Meltem, Uslu; Fernando, Valenzuela; Solange, Valle; Martijn, van Doorn; Jirina, Vankova; Suneel, Vartak; Christine, Vidouria; Sebastian, Volc; Gerald, Volcheck; Nicola, Wagner; Irena, Walecka-Herniczek; Penpun, Wattanakrai; Bettina, Wedi; Steven, Weinstein; Vesarat, Wessagowit; Hugh, Windom; Akiko, Yagami; Aisaku, Yamamoto; Shinichiro, Yasumoto; Young Min, Ye; Jose Cevallos, Yepez; Sang Woong, Youn; Hana, Zelenkova; Oleg, Ziganshin; Matthew, Zook
Source
The Lancet; 20230101, Issue: Preprints
Subject
Language
ISSN
01406736; 1474547X
Abstract
Many patients with chronic spontaneous urticaria (CSU) do not achieve complete control of their symptoms with current available treatments. In a dose-finding phase 2b study, ligelizumab improved urticaria symptoms in patients with H1-antihistamine (H1-AH) refractory CSU. Here, we report the efficacy and safety outcomes from two ligelizumab phase 3 studies.