부산대학교 도서관

AIM: We sought to determine the relationship between age, and other clinical characteristics such as parity, oestrogen use, dietary factors and menstrual history on breast density in Jamaican women. METHODS AND MATERIALS: A retrospective study was done of 891 patients who attended the breast imaging unit. The clinical characteristics were extracted from the patient records. Mammograms were assessed independently by two radiologists who were blinded to the patient clinical characteristics. Breast densities were assigned using the American College of Radiology (ACR) classification. RESULTS: The concordance between the ACR classification of breast density between the two independent radiologists was 92% with k=0.76 (SE=0.02, P<0.001). Women with low breast density were heavier (81.3±15.5kg vs 68.4±14.3kg,P<0.0001, mean±standard deviation (SD)) and more obese (body mass index (BMI), 30.3±5.8kg m−2vs 26.0±5.2kg m−2,P<0.0001). Mammographic breast density decreased with age. The age adjusted odds ratios (ORs) for predictors significantly related to high breast density were parity, OR=0.79 (95%CI:0.71, 0.88), weight, OR=0.92 (95% CI:0.91, 0.95), BMI, OR=0.83 (95% CI:0.78, 0.89), menopause, OR=0.51 (95% CI:0.36, 0.74) and a history of previous breast surgery, OR 1.6 (95% CI:1.1, 2.3). CONCLUSION: The rate decline of breast density with age in our population was influenced by parity and body composition.Soares, D. et al. (2002). Clinical Radiology57, 472–476.