학술논문
Effect of the Metal Center on the Antitumor Activity of the Analogous Dinuclear Spermine Chelates (PdCl2)2(Spermine) and (PtCl2)2(Spermine)
Document Type
Article
Author
Source
Letters in Drug Design & Discovery; October 2007, Vol. 4 Issue: 7 p460-463, 4p
Subject
Language
ISSN
15701808
Abstract
The cytotoxic activity of (PdCl2)2(spermine) against a human cancer cell line (HSC-3) was evaluated. The results show an activity higher than that of the analogous Pt(II) chelate and, for 24 h incubations, identical to that of cisplatin. They also suggest a faster intracellular uptake and DNA binding relative to cisplatin.