학술논문
Formation of donor-specific human leukocyte antigen antibodies after kidney transplantation correlation with acute rejection and tapering of immunosuppression
Document Type
Article
Author
Source
Transplantation; March 2003, Vol. 75 Issue: 6 p871-877, 7p
Subject
Language
ISSN
00411337; 15346080
Abstract
Before kidney transplantation, a serological crossmatch is routinely performed between donor and recipient to prevent hyperacute rejection by donor-specific anti-human leukocyte antigen (HLA) antibodies. After transplantation, the presence of these antibodies is not routinely monitored. We wanted to know whether donor-specific anti-HLA antibodies are detectable during acute rejection (AR), before or after reduction of immunosuppression in kidney transplant recipients who were converted from cyclosporine A (CsA) to the less nephrotoxic azathioprine (AZA) or mycophenolate mofetil (MMF) at 1 year after transplantation.