학술논문
Preclinical development of an oral anti-Wolbachiamacrolide drug for the treatment of lymphatic filariasis and onchocerciasis
Document Type
Article
Author
Taylor, Mark J.; von Geldern, Thomas W.; Ford, Louise; Hübner, Marc P.; Marsh, Kennan; Johnston, Kelly L.; Sjoberg, Hanna T.; Specht, Sabine; Pionnier, Nicolas; Tyrer, Hayley E.; Clare, Rachel H.; Cook, Darren A. N.; Murphy, Emma; Steven, Andrew; Archer, John; Bloemker, Dominique; Lenz, Franziska; Koschel, Marianne; Ehrens, Alexandra; Metuge, Haelly M.; Chunda, Valerinne C.; Ndongmo Chounna, Patrick W.; Njouendou, Abdel J.; Fombad, Fanny F.; Carr, Robert; Morton, Howard E.; Aljayyoussi, Ghaith; Hoerauf, Achim; Wanji, Samuel; Kempf, Dale J.; Turner, Joseph D.; Ward, Stephen A.
Source
Science Translational Medicine; March 2019, Vol. 11 Issue: 483
Subject
Language
ISSN
19466234; 19466242
Abstract
An oral macrolide drug targeting the bacterial endosymbiont, Wolbachia, shows efficacy against filarial nematodes in preclinical animal models.