학술논문
Endothelin-1 is involved in plasma mediated stimulation of neutrophil adherence during coronary artery bypass grafting.
Document Type
Article
Source
European Journal of Cardio-Thoracic Surgery; April 1999, Vol. 15 Issue: 4 p408-412, 5p
Subject
Language
ISSN
10107940; 1873734X
Abstract
Myocardial ischaemia followed by reperfusion during coronary artery bypass grafting (CABG) is known to result in the activation of polymorphonuclear neutrophils (PMN). The activation of PMN during ischaemia/reperfusion may be a result of their direct contact with activated endothelial cells and/or an effect of stimuli released from ischaemic myocardium. Increased expression of adhesion molecules on the PMN surface, after activation, leads to coronary capillary plugging with a subsequent decrease in blood flow. The purpose of the study was to evaluate plasma-mediated stimulation of PMN adhesion during CABG and to verify if endothelin-1 (ET-1), known to be a potent stimulus for PMN, is involved in stimulation of neutrophils adhesion mediated by integrins.