학술논문
Different sensitivities of the responses of human neutrophils stimulated with immune complex and C5a anaphylatoxin to pertussis toxin
Document Type
Article
Source
FEBS Letters; January 1988, Vol. 234 Issue: 1 p231-234, 4p
Subject
Language
ISSN
00145793
Abstract
When stimulated with immune complex or C5a anaphylatoxin, human neutrophils undergo an increase in the concentration of intracellular Ca 2+([Ca 2+] i) that precedes the onset of superoxide (O −2) production. The extracellular Ca 2+is required for the O −2production of neutrophils stimulated by C5a, but is only partially required for those by immune complex. The addition of pertussis toxin to neutrophils does not inhibit the rise in [Ca 2+] iand O −2production induced by immune complex but does inhibit those induced by C5a. These results suggest that a different sequence of reaction is involved by different stimulants, the anaphylatoxin and immune complex.