학술논문
Conversion from Intravenous to Sustained-Release Oral Theophylline in Pediatric Patients with Asthma
Document Type
Article
Source
The Annals of Pharmacotherapy; September 1986, Vol. 20 Issue: 9 p700-703, 4p
Subject
Language
ISSN
10600280; 15426270
Abstract
A method for converting pediatric patients from intravenous aminophylline to sustained-release oral theophylline was evaluated in eight asthmatic children. The administration of Theo-Dur tablets two hours before discontinuation of a continuous intravenous aminophylline infusion resulted in a peak rise of 5.6 ± 3.0 /tg/ml over steady-state serum theophylline concentrations. This method of conversion is acceptable in children with equivalent oral and intravenous doses of theophylline and serum theophylline concentrations <15 /ig/ml. Children with steady-state theophylline concentrations >15 /ig/ml are likely to develop concentrations exceeding the therapeutic range using this conversion method.