학술논문
Relationship between Changes in Thymic Emigrants and Cell-Associated HIV-1 Dna in HIV-1-Infected Children Initiating Antiretroviral Therapy
Document Type
Article
Author
De Rossi, Anita; Walker, A Sarah; Forni, Davide De; Klein, Nigel; Gibb, Diana M; Aboulker, J-P; Babiker, A; Compagnucci, A; Darbyshire, J; Debré, M; Gersten, M; Giaquinto, C; Gibb, DM; Jones, A; Aboulker, J-P; Babiker, A; Blanche, S; Bohlin, A-B; Butler, K; Castelli-Gattinara, G; Clayden, P; Darbyshire, J; Debré, M; de Groot, R; Faye, A; Giaquinto, C; Gibb, DM; Griscelli, C; Grosch-Wörner, I; Levy, J; Lyall, H; Mellado Pena, M; Nadal, D; Peckham, C; Ramos Amador, JT; Rosado, L; Rudin, C; Scherpbier, H; Sharland, M; Tovo, PA; Valerius, N; Wintergerst, U; Boucher, C; Clerici, M; de Rossi, A; Klein, N; Loveday, C; Muñoz-Fernandez, M; Pillay, D; Rouzioux, C; Babiker, A; Darbyshire, J; Gibb, DM; Harper, L; Johnson, D; Kelleher, P; McGee, L; Poland, A; Walker, AS; Aboulker, J-P; Carrière, I; Compagnucci, A; Debré, M; Eliette, V; Leonardo, S; Moulinier, C; Saidi, Y; Galli, L; Foot, A; Kershaw, H; Caul, O; Tarnow-Mordi, W; Petrie, J; McIntyre, P; Appleyard, K; Gibb, DM; Novelli, V; Klein, N; McGee, L; Ewen, S; Johnson, M; Gibb, DM; Cooper, E; Fisher, T; Barrie, R; Norman, J; King, D; Larsson-Sciard, E-L
Source
Antiviral Therapy; January 2005, Vol. 10 Issue: 1 p63-71, 9p
Subject
Language
ISSN
13596535
Abstract
Objectives and methods To investigate the relationship between cell-associated HIV-1 dynamics and recent thymic T-cell emigrants, HIV-1 DNA and T-cell receptor rearrangement excision circles (TREC, a marker of recent thymic emigrants) were measured in peripheral blood mononuclear cells in 181 samples from 33 HIV-1-infected children followed for 96 weeks after antiretroviral therapy (ART) initiation.Results At baseline, HIV-1 DNA was higher in children with higher TREC (P=0.02) and was not related to age, CD4 or HIV-1 RNA in multivariate analyses (P>0.3). Overall, TREC increased and HIV-1 DNA decreased significantly after ART initiation, with faster HIV-1 DNA declines in children with higher baseline TREC (P=0.009). The greatest decreases in HIV-1 DNA occurred in children with the smallest increases in TREC levels during ART (P=0.002). However, this inverse relationship between changes in HIV-1 DNA and TREC tended to vary according to the phase of HIV-1 RNA decline (P=0.13); for the same increase in TREC, HIV-1 DNA decline was much smaller during persistent or transient viraemia compared with stable HIV-1 RNA suppression.Conclusions Overall, these findings indicate that TREC levels predict HIV-1 DNA response to ART and suggest that immune repopulation by thymic emigrants adversely affects HIV-1 DNA decline in the absence of persistent viral suppression, possibly by providing a cellular source for viral infection and replication.