학술논문
10-day decitabine versus 3 + 7 chemotherapy followed by allografting in older patients with acute myeloid leukaemia: an open-label, randomised, controlled, phase 3 trial
Document Type
Article
Author
Lübbert, Michael; Wijermans, Pierre W; Kicinski, Michal; Chantepie, Sylvain; Van der Velden, Walter J F M; Noppeney, Richard; Griškevičius, Laimonas; Neubauer, Andreas; Crysandt, Martina; Vrhovac, Radovan; Luppi, Mario; Fuhrmann, Stephan; Audisio, Ernesta; Candoni, Anna; Legrand, Olivier; Foà, Robin; Gaidano, Gianluca; van Lammeren-Venema, Danielle; Posthuma, Eduardus F M; Hoogendoorn, Mels; Giraut, Anne; Stevens-Kroef, Marian; Jansen, Joop H; de Graaf, Aniek O; Efficace, Fabio; Ammatuna, Emanuele; Vilque, Jean-Pierre; Wäsch, Ralph; Becker, Heiko; Blijlevens, Nicole; Dührsen, Ulrich; Baron, Frédéric; Suciu, Stefan; Amadori, Sergio; Venditti, Adriano; Huls, Gerwin; Finke, Jürgen; Schaap, Nicolaas Petrus Michael; Zucenka, Andrius; Metzelder, Stephan; Jost, Edgar; Perić, Zinaida; Forghieri, Fabio; Allione, Bernadino; Martelli, Maurizio; Iori, Anna Paola; Wittnebel, Sebastian; Mengarelli, Andrea; Imovilli, Annalisa; Olivieri, Attilio; De Prijck, Bernard José Marie; van der Poel, Marjolein W.M.; Junghanß, Christian; Salih, Helmut Rainer; Tafuri, Agostino; Guimarães, José Eduardo; Musso, Maurizio; De Fabritiis, Paolo; Chevallier, Patrice; Selleslag, Dominik Luc; Cascavilla, Nicola; Berneman, Zwi; Jaspers, Aurélie; Zuffa, Eliana; Vanstraelen, Gaëtan; Visani, Giuseppe; Cuijpers, Maria Louisa Henriëtte; De Becker, Ann; Mianulli, Anna Maria; Hackanson, Björn; Mihaylov, Georgi Georgiev; Martinelli, Giovanni; Paolini, Stefania; Zinzani, Pier Luigi; Henkes, Martin; Al-Ali, Haifa Kathrin; La Rosée, Paul; Chierichini, Anna; Cudillo, Laura; Specchia, Giorgina; Šimec, Njetočka Gredelj; Capalbo, Silvana Franca; Spinosa, Giuseppina; Molica, Stefano; de Jonge-Peeters, Susan Dorothé
Source
The Lancet Haematology; November 2023, Vol. 10 Issue: 11 pe879-e889, 11p
Subject
Language
ISSN
23523026
Abstract
Many older patients with acute myeloid leukaemia die or cannot undergo allogeneic haematopoietic stem-cell transplantation (HSCT) due to toxicity caused by intensive chemotherapy. We hypothesised that replacing intensive chemotherapy with decitabine monotherapy could improve outcomes.