학술논문
Synthesis of Antioxidants for Prevention of Age-Related Macular Degeneration
Document Type
Article
Author
Source
Journal of Natural Products; March 2013, Vol. 76 Issue: 3 p450-454, 5p
Subject
Language
ISSN
01633864; 15206025
Abstract
Photooxidation of A2E may be involved in diseases of the macula, and antioxidants could serve as therapeutic agents for these diseases. Inhibitors of A2E photooxidation were prepared by Mannich reaction of the antioxidant quercetin. These compounds contain water-solubilizing amine groups, and several were more potent inhibitors of A2E photooxidation than quercetin.