학술논문
INCIDENCE OF NEW-ONSET HYPERCHOLESTEROLEMIA IN RENAL TRANSPLANT PATIENTS TREATED WITH FK506 OR CYCLOSPORINE1
Document Type
Article
Author
Source
Transplantation; February 1998, Vol. 65 Issue: 3 p446-449, 4p
Subject
Language
ISSN
00411337; 15346080
Abstract
In this study, we compare cholesterol levels during the first year after renal transplantation in FK506 (Prograf)- and cyclosporine-treated patients matched for cumulative first-year steroid dose and hypercholesterolemia risk factors. All patients had pretransplant cholesterol levels <200 mg/dl. At 3 months posttransplant, 68% of the cyclosporine-treated patients had at least one cholesterol level greater than 200 mg/dl compared with 30% of the FK506-treated patients(P<0.05). At the end of the year, 26% of FK506- and 67% of cyclosporine-treated patients remained hypercholesterolemic(P<0.05). We conclude that cyclosporine has inherently more effect on cholesterol levels than FK506 during the first year after kidney transplantation.