학술논문
Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3): a double-blind, randomised, placebo-controlled phase 3 trial
Document Type
Article
Author
Dimopoulos, Meletios A; Gay, Francesca; Schjesvold, Fredrik; Beksac, Meral; Hajek, Roman; Weisel, Katja Christina; Goldschmidt, Hartmut; Maisnar, Vladimir; Moreau, Philippe; Min, Chang Ki; Pluta, Agnieszka; Chng, Wee-Joo; Kaiser, Martin; Zweegman, Sonja; Mateos, Maria-Victoria; Spencer, Andrew; Iida, Shinsuke; Morgan, Gareth; Suryanarayan, Kaveri; Teng, Zhaoyang; Skacel, Tomas; Palumbo, Antonio; Dash, Ajeeta B; Gupta, Neeraj; Labotka, Richard; Rajkumar, S Vincent; Bar, Daniel; Basso, Alfredo; Fantl, Dorotea; He, Simon; Horvath, Neomi; Lee, Cindy; Rowlings, Phillip; Taylor, Kerry; Spencer, Andrew; Cochrane, Tara; Kwok, Fiona; Ramanathan, Sundreswran; Agis, Hermine; Zojer, Niklas; Kentos, Alain; Offner, Fritz; Van Droogenbroeck, Jan; Wu, Ka Lung; Maiolino, Angelo; Martinez, Gracia; Zanella, Karla; Capra, Marcelo; Araújo, Sérgio; Gregora, Evzen; Hajek, Roman; Maisnar, Vladimir; Pour, Ludek; Scudla, Vlastimil; Spicka, Ivan; Abildgaard, Niels; Andersen, Niels; Jensen, Bo Amdi; Helleberg, Carsten; Plesner, Torben; Salomo, Morten; Svirskaite, Asta; Delarue, Richard; Moreau, Philippe; Blau, Igor; Goldschmidt, Hartmut; Schieferdecker, Aneta; Teleanu, Veronica; Munder, Markus; Röllig, Christoph; Salwender, Han-Juergen; Fuhrmann, Stephan; Weisel, Katja; Duerig, Jan; Zeis, Matthias; Klein, Stefan; Reimer, Peter; Schmidt, Christian; Scheid, Christof; Mayer, Karin; Hoffmann, Martin; Sosada, Markus; Dimopoulos, Athanasios; Delimpasi, Sosana; Kyrtsonis, Mary-Christine; Anagnostopoulos, Achilleas; Nagy, Zsolt; Illés, Árpád; Egyed, Miklós; Borbényi, Zita; Mikala, Gabor; Dally, Najib; Horowitz, Netanel; Gutwein, Odit; Nemets, Anatoly; Vaxman, Iuliana; Shvetz, Olga; Trestman, Svetlana; Ruchlemer, Rosa; Nagler, Arnon; Tadmor, Tamar; Rouvio, Ory; Preis, Meir; Gay, Francesca; Cavo, Michele; De Rosa, Luca; Musto, Pellegrino; Cafro, Anna; Tosi, Patrizia; Offidani, Massimo; Corso, Alessandro; Rossi, Giuseppe; Liberati, Anna Marina; Bosi, Alberto; Suzuki, Kenshi; Iida, Shinsuke; Nakaseko, Chiaki; Ishikawa, Takayuki; Matsumoto, Morio; Nagai, Hirokazu; Sunami, Kazutaka; Chou, Takaaki; Akashi, Koichi; Takezako, Naoki; Hagiwara, Shotaro; Eom, Hyeon Seok; Jo, Deog-Yeon; Kim, Jin Seok; Lee, Jae Hoon; Min, Chang Ki; Yoon, Sung Soo; Yoon, Dok Hyun; Kim, Kihyun; Zweegman, Sonja; Levin, Mark-David; Vellenga, Edo; Minnema, Monique; Schjesvold, Fredrik; Waage, Anders; Haukås, Einar; Grosicki, Sebastian; Pluta, Andrzej; Robak, Tadeusz; Marques, Herlander; Bergantim, Rui; Campilho, Fernando; Chng, Wee Joo; Goh, Yeow Tee; McDonald, Andrew; Rapoport, Bernado; Álvarez Rivas, Miguel Angel; De Arriba de La Fuente, Felipe; González Montes, Yolanda; Martin Sanchez, Jesus; Mateos, Maria Victoria; Oriol Rocafiguera, Albert; Rosinol, Laura; San Miguel, Jesús; Pérez de Oteyza, Jaime; Encinas, Cristina; Alegre-Amor, Adrian; López-Guía, Ana; Axelsson, Per; Carlson, Kristina; Stromberg, Olga; Hansson, Markus; Hveding Blimark, Cecile; Mueller, Rouven; Chen, Chih-Cheng; Liu, Ta-Chih; Huang, Shang-Yi; Wang, Po-Nan; Na Nakorn, Thanyaphong; Prayongratana, Kannadit; Beksac, Meral; Unal, Ali; Goker, Hakan; Sonmez, Mehmet; Korenkova, Sybiryna; Chaidos, Aristeidis; Oakervee, Heather; Sati, Hamdi; Benjamin, Reuben; Wechalekar, Ashutosh; Garg, Mamta; Kaiser, Martin; Ramasamy, Karthik; Cook, Gordon; Chantry, Andrew; Jenner, Matthew; Buadi, Francis; Berryman, Robert; Janakiram, Murali
Source
The Lancet; January 2019, Vol. 393 Issue: 10168 p253-264, 12p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Maintenance therapy following autologous stem cell transplantation (ASCT) can delay disease progression and prolong survival in patients with multiple myeloma. Ixazomib is ideally suited for maintenance therapy given its convenient once-weekly oral dosing and low toxicity profile. In this study, we aimed to determine the safety and efficacy of ixazomib as maintenance therapy following ASCT.