학술논문
The impact of first trimester fasting glucose level on adverse perinatal outcome
Document Type
Article
Author
Source
Journal of Perinatology; 20240101, Issue: Preprints p1-5, 5p
Subject
Language
ISSN
07438346; 14765543
Abstract
To evaluate the impact of first trimester fasting glucose (FTFG) level on perinatal outcome. A retrospective cohort study of singleton deliveries. Maternal and neonatal outcome were compared between two groups—women with FTFG?95?mg/dl and FTFG?=?95?mg/dl. Women with pre-gestational diabetes were excluded. Five thousand and thirty women met inclusion criteria. Of whom, 4644 (92.3%) had FTFG?95?mg/dl and 386 (7.7%) had FTFG?=?95?mg/dl. Women with FTFG?=?95?mg/dl had higher rates of gestational hypertension (2.33 vs. 0.7%) and gestational diabetes (9.07 vs. 2.86%), p?0.05 for both. Moreover, they had higher rates of cesarean delivery and arrest of descent, p?0.05. Composite diabetes outcome was significantly higher among women with FTFG?=?95?mg/dl (8 vs. 3%, p?=?0.002). After adjusting for potential confounders, composite diabetes outcome (aOR?=?1.942 95% CI 1.265–2.981, p?=?0.002) and gestational hypertension (aOR?=?2.827 95% CI 1.295–6.175, p?=?0.009) remained significantly higher in the FTFG?=?95?mg/dl group. FTFG?=?95?mg/dl is an independent risk factor for adverse perinatal outcome including gestational hypertension and diabetes-related complications.