학술논문
Stem-cell-derived human microglia transplanted in mouse brain to study human disease
Document Type
Article
Author
Mancuso, Renzo; Van Den Daele, Johanna; Fattorelli, Nicola; Wolfs, Leen; Balusu, Sriram; Burton, Oliver; Liston, Adrian; Sierksma, Annerieke; Fourne, Yannick; Poovathingal, Suresh; Arranz-Mendiguren, Amaia; Sala Frigerio, Carlo; Claes, Christel; Serneels, Lutgarde; Theys, Tom; Perry, V. Hugh; Verfaillie, Catherine; Fiers, Mark; De Strooper, Bart
Source
Nature Neuroscience; December 2019, Vol. 22 Issue: 12 p2111-2116, 6p
Subject
Language
ISSN
10976256; 15461726
Abstract
Although genetics highlights the role of microglia in Alzheimer’s disease, one-third of putative Alzheimer’s disease risk genes lack adequate mouse orthologs. Here we successfully engraft human microglia derived from embryonic stem cells in the mouse brain. The cells recapitulate transcriptionally human primary microglia ex vivo and show expression of human-specific Alzheimer’s disease risk genes. Oligomeric amyloid-ß induces a divergent response in human versus mouse microglia. This model can be used to study the role of microglia in neurological diseases.