학술논문
Topical anti-inflammatory activity of extracts and compounds from Thymus broussonettii
Document Type
Article
Author
Source
Journal of Pharmacy and Pharmacology; August 2002, Vol. 54 Issue: 8 p1137-1140, 4p
Subject
Language
ISSN
00223573; 20427158
Abstract
The topical anti-inflammatory activity of four extracts from Thymus broussonetiiBoiss (Labiatae) leaves, a herbal drug used in Moroccan traditional medicine, has been studied using the croton oil ear test in mice. A bioassay-oriented fractionation revealed that the pharmacological activity is mainly in the chloroform extract. Fractionation and analysis of this extract allowed the identification of ursolic acid and oleanolic acid as the main anti-inflammatory principles. Some flavonoids (luteolin, eriodictyol, thymonin) and glycosides (luteolin-7-O-glucoside, luteolin-3′-O-glucuronide, eriodictyol-7-O-glucoside) were also isolated from the methanol extract.