학술논문
In silicoprediction of T- and B-cell epitopes in PmpD: First step towards to the design of a Chlamydia trachomatisvaccine
Document Type
Article
Source
Biomedical Journal; April 2018, Vol. 41 Issue: 2 p109-117, 9p
Subject
Language
ISSN
23194170; 23202890
Abstract
Chlamydia trachomatisis the most common sexually transmitted bacterial infection globally. Currently, there are no vaccines available despite the efforts made to develop a protective one. Polymorphic membrane protein D (PmpD) is an attractive immunogen candidate as it is conserved among strains and it is target of neutralizing antibodies. However, its high molecular weight and its complex structure make it difficult to handle by recombinant DNA techniques. Our aim is to predict B-cell and T-cell epitopes of PmpD.