학술논문
3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial
Document Type
Article
Author
le Roux, Carel W; Astrup, Arne; Fujioka, Ken; Greenway, Frank; Lau, David C W; Van Gaal, Luc; Ortiz, Rafael Violante; Wilding, John P H; Skjøth, Trine V; Manning, Linda Shapiro; Pi-Sunyer, Xavier; Hamann, Andreas; Barakat, Alain; Blüher, Matthias; Linn, Thomas; Mölle, Andrea; Segner, Alexander; Stübler, Petra; Tosch-Sisting, Regina; Pacini, Furio; Santini, Ferruccio; Marchesini, Giulio; Rotella, Carlo Maria; Invitti, Cecilia; Vettor, Roberto; Buscemi, Silvio; Raya, Pedro Mezquita; Freijoo, Felipe Casanueva; de Barbará, Ramón Gomis; Carraro, Raffaele; Bobillo, Enrique Romero; de la Cuesta, Carmen; Farsang, Csaba; Csaszar, Albert; Zahorska-Markiewicz, Barbara; Pupek-Musialik, Danuta; Franek, Edward; Ostrowska, Lucyna; Olszanecka-Glinianowicz, Magdalena; Lalic, Nebojsa; Micic, Dragan; Ludvik, Bernhard; Paulweber, Bernhard; Prager, Rudolf; Scheen, André; Van Gaal, Luc; Astrup, Arne Vernon; Hermansen, Kjeld; Madsbad, Sten; Rissanen, Aila; Nieminen, Sakari; Savolainen, Markku; Krempf, Michel; Romon, Monique; Laville, Martine; Marre, Michel; Mira, Reginald; Finucane, Francis; Veenendaal, Aletha; van Berkum, Frank; Johannsson-Vidarsdóttir, Solrun; Van de Walle, Vivienne; Meesters, Eelco; Hjelmesæth, Jøran; Klemsdal, Tor Ole; Kulseng, Bård; Bach-Kliegel, Birgit; Laederach, Kurt; Villiger, Lukas; Golay, Alain; Bilz, Stefan; Sathyapalan, Thozhukat; Bain, Stephen; Kumar, Sudesh; Le Roux, Carel Wynard; Lean, Michael E.J.; McGowan, Barbara; Rehman, Tariq; Wilding, John; Wittert, Gary; Caterson, Ian; Proietto, Joeseph; Prins, John; Neto, Bruno Geloneze; Gross, Jorge Luiz; Chacra, Antonio Roberto; Halpern, Alfredo; de Almeida Suplicy, Henrique; Chow, Francis Chun Chung; Thacker, Hemant P; Chadha, Manoj; Chandalia, Hemaraj; Unnikrishnan, Ambika; Kalra, Sanjay; Deshpande, Neeta; Shunmugavelu, Minakshi; Deshmukh, Vaishali Chetan; Maislos, Maximo; Lieberman, Gabriella Segal; Shimon, Ilan; Stern, Naftali; Nabriski, Dan; Karnieli, Eddy; Shehadeh, Naim; Gonzalez-Galvez, Guillermo; del Rosario Arechavaleta-Granell, Maria; Ortiz, Rafael Margarito Violante; Franco, Guadalupe Morales; Gurieva, Irina; Suplotova, Lyudmila Aleksandrovna; Troshina, Ekaterina; Ruyatkina, Ludmila Aleksandrovna; Voychik, Emma Anatolievna; Martsevich, Sergey; Startseva, Maria A; Seeber, Mary Elizabeth; Badat, Aysha; Ellis, Graham; Altuntas, Yuksel; Guler, Serdar; Ulgen, Ender; Delibasi, Tuncay; Chetty, Tony; Hart, Randy; Janzen, Jeannette; Labonte, Isabelle; Lau, David; Liutkus, Joanne; O'Keefe, Dennis; Padwal, Raj; Ransom, Thomas P.P.; Tytus, Richard; Weisnagel, Stanley John; Adler, Jay; Aqua, Keith; Aronoff, Stephen L; Bedel, Gary W.; Blevins, Thomas Craig; Blumenau, Joe; Brockmyre, Andrew Peter; Call, Robert S; Canadas, Rafael; Chaykin, Louis B; Cohen, Kenneth; Conrow, Jeffrey Keith; Davis, Matthew G; Downey, H Jackson; Drosman, Steven Richard; Duckor, Steven; Farmer, H. Frank; Farrell, James; Fehnel, Stephen; Finneran, Matthew Patrick; Forbes, Ray; Forker, Alan; Fredrick, Mark; Fujioka, Ken; Geller, Steven Andrew; Gill, Santosh; Glaser, Linda; Greco, Susan Neims; Greenway, Frank Lyons; Harper, Wayne; Herman, Lee; Hoekstra, John; Ingebretsen, Richard; Ison, Rodney; Jain, Rajeev K; Kaplan, Roy; Kaster, Steven Richard; Haase, Gregory A; Kerzner, Boris; Kirstein, Judith Lee; Koltun, William; Krieger, Diane R; Lewis, Cora Elizabeth; Madder, Robert; Marple, Richard N; McDermott, Edward J; Mello, Curtis John; Miller, Alan B.; Mullen, Julie; Nardandrea, John; O'Neil, Patrick; Pi-Sunyer, F. Xavier; Pucillo, Ronald M; Rhee, Chanhaeng; Redrick, Scott; Pardini, Aaron; Rothman, Jeffrey; Rubino, Domenica Marie; Sellers, Gladstone; Smith, Timothy; Byars, William David; Soufer, Joseph; Sussman, Allen Michael; Patrick, Kyle; Schramm, Erich Lloyd; Van Cleeff, Martin; Berg, Saul Reuel; Wyatt, Holly Roxanna; Simon, James Alan
Source
The Lancet; April 2017, Vol. 389 Issue: 10077 p1399-1409, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose metabolism after the 56-week period of this trial, one of four trials in the SCALE programme. In the 3-year assessment of the SCALE Obesity and Prediabetes trial we aimed to evaluate the proportion of individuals with prediabetes who were diagnosed with type 2 diabetes.