학술논문
Proton pump Inhibitors Versus CryptococcusSpecies: Effects on in VitroSusceptibility and Melanin Production
Document Type
Article
Author
Source
Future Microbiology; April 2019, Vol. 14 Issue: 6 p489-497, 9p
Subject
Language
ISSN
17460913; 17460921
Abstract
Aim:This study aimed to evaluate the effects of proton pump inhibitors (PPIs) on growth and melanin production by Cryptococcusspp. Materials & methods:Minimum inhibitory concentrations (MICs) of omeprazole, esomeprazole, rabeprazole, pantoprazole and lansoprazole against Cryptococcusspp. were determined and the effect of PPIs on melanin production was evaluated, in the presence or absence of copper sulfate or glutathione. Results:PPIs showed MICs ranging from 125–1000μg/ml and decreased melanization by Cryptococcuscells. Addition of copper sulfate or gluthatione restored melanogenesis of cells grown in the presence of PPIs. The presence of PPIs and glyphosate decreased copper sulfate toxicity (1mM). Conclusion:PPIs inhibited melanogenesis of Cryptococcusspp., possibly by chelating copper or inhibiting copper ATPase transport.