학술논문
Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study
Document Type
Article
Author
Chanchlani, Neil; Lin, Simeng; Bewshea, Claire; Hamilton, Benjamin; Thomas, Amanda; Smith, Rebecca; Roberts, Christopher; Bishara, Maria; Nice, Rachel; Lees, Charlie W; Sebastian, Shaji; Irving, Peter M; Russell, Richard K; McDonald, Timothy J; Goodhand, James R; Ahmad, Tariq; Kennedy, Nicholas A; Patel, Vinod; Mazhar, Zia; Saich, Rebecca; Colleypriest, Ben; Tham, Tony C; Iqbal, Tariq; Kaushik, Vishal; Murugesan, Senthil; Singh, Salil; Weaver, Sean; Preston, Cathryn; Butt, Assad; Smith, Melissa; Basude, Dharamveer; Beale, Amanda; Langlands, Sarah; Direkze, Natalie; Parkes, Miles; Torrente, Franco; De La Revella Negro, Juan; MacDonald, Chris Ewen; Evans, Stephen M; Gunasekera, Anton VJ; Thakur, Alka; Elphick, David; Shenoy, Achuth; Nwokolo, Chuka U; Dhar, Anjan; Cole, Andrew T; Agrawal, Anurag; Bridger, Stephen; Doherty, Julie; Cooper, Sheldon C; de Silva, Shanika; Mowat, Craig; Mayhead, Phillip; Lees, Charlie; Jones, Gareth; Ahmad, Tariq; Hart, James W; Kennedy, Nicholas A; Goodhand, James R; Lin, Simeng; Chanchlani, Neil; Nice, Rachel; McDonald, Timothy J; Bewshea, Claire; Al-Nuaimi, Yusur; Richards, Ellen; Haigh, Richard; Greenish, Huw; Heath, Harry; Gaya, Daniel R; Russell, Richard K; Gervais, Lisa; Dunckley, Paul; Mahmood, Tariq; Banim, Paul JR; Sonwalkar, Sunil; Ghosh, Deb; Phillips, Rosemary H; Azaz, Amer; Sebastian, Shaji; Shenderey, Richard; Armstrong, Lawrence; Bell, Claire; Hariraj, Radhakrishnan; Matthews, Helen; Jafferbhoy, Hasnain; Selinger, Christian P; Zamvar, Veena; De Caestecker, John S; Willmott, Anne; Miller, Richard; Babu, Palani Sathish; Tzivinikos, Christos; Bloom, Stuart L; Chung-Faye, Guy; Croft, Nicholas M; Fell, John ME; Harbord, Marcus; Hart, Ailsa; Hope, Ben; Irving, Peter M; Lindsay, James O; Mawdsley, Joel E; McNair, Alistair; Monahan, Kevin J; Murray, Charles D; Orchard, Timothy; Paul, Thankam; Pollok, Richard; Shah, Neil; Bouri, Sonia; Johnson, Matt W; Modi, Anita; Kabiru, Kasamu Dawa; Baburajan, B K; Bhaduri, Bim; Fagbemi, Andrew Adebayo; Levison, Scott; Limdi, Jimmy K; Watts, Gill; Foley, Stephen; Ramadas, Arvind; MacFaul, George; Mansfield, John; Grellier, Leonie; Morris, Mary-Anne; Tremelling, Mark; Hawkey, Chris; Kirkham, Sian; Charlton, Charles PJ; Rodrigues, Astor; Simmons, Alison; Lewis, Stephen J; Snook, Jonathon; Tighe, Mark; Goggin, Patrick M; De Silva, Aminda N; Lal, Simon; Smith, Mark S; Panter, Simon; Cummings, JR Fraser; Dharmisari, Suranga; Carter, Martyn; Watts, David; Mahmood, Zahid; McLain, Bruce; Sen, Sandip; Pigott, Anna J; Hobday, David; Wesley, Emma; Johnston, Richard; Edwards, Cathryn; Beckly, John; Vani, Deven; Ramakrishnan, Subramaniam; Chaudhary, Rakesh; Trudgill, Nigel J; Cooney, Rachel; Bell, Andy; Prasad, Neeraj; Gordon, John N; Brookes, Matthew J; Li, Andy; Gore, Stephen
Source
The Lancet Gastroenterology & Hepatology; 20240101, Issue: Preprints
Subject
Language
ISSN
24681253
Abstract
We sought to report the effectiveness of infliximab and adalimumab over the first 3 years of treatment and to define the factors that predict anti-TNF treatment failure and the strategies that prevent or mitigate loss of response.