학술논문
Maturation and insulin-like immunoreactivity in rat submandibular salivary glands: possible implication of G regulatory proteins
Document Type
Article
Source
European Journal of Endocrinology; April 1992, Vol. 126 Issue: 4 p282-284, 3p
Subject
Language
ISSN
08044643; 1479683X
Abstract
Streptozotocin-induced diabetes is accompanied by an increase in insulin-like immunoreactivity concentration in rat submandibular salivary glands. In this study we have examined whether, in normal state, maturation is accompanied by changes in insulin-like immunoreactivity concentration of rat submandibular salivary glands. Insulin-like immunoreactivity concentrations of submandibular salivary glands were significantly higher in 11 months old rats compared with 3.5 months old control animals. A pertussis toxin pretreatment provoked an increase in insulin-like immunoreactivity, suggesting that a pertussis toxin sensitive G-protein is involved in the regulation of insulin-like immunoreactivity in the rat submandibular salivary glands.