학술논문
Catalytic Asymmetric Decarboxylative Michael Addition To Construct an All-Carbon Quaternary Center with 3-Alkenyl-oxindoles
Document Type
Article
Author
Source
Organic Letters; April 2022, Vol. 24 Issue: 14 p2585-2589, 5p
Subject
Language
ISSN
15237060; 15237052
Abstract
The first highly enantioselective asymmetric decarboxylative addition of β-keto acids with 3-alkenyl-oxindoles bearing an all-carbon quaternary stereocenter have been developed. The relevant products were acquired in 49–98% yields with 88–98% enantioselectivities in the presence of 0.04–1.0 mol % of chiral rhodium catalyst. The comprehensive practicability of this method was proven in the preparation of the key intermediate, which can be easily transformed into analogues of physovenine and physostigmine.