학술논문
212. Abstoßungsmechanismen nach xenogener Herztransplantation unter Cyclosporin A-Therapie
Document Type
Article
Source
Langenbeck's Archives of Surgery; December 1984, Vol. 364 Issue: 1 p536-536, 1p
Subject
Language
ISSN
14352443; 14352451
Abstract
Summary In order to look at the effects of Cyclosporine A on the mechanisms of rejection after xenogeneic heart transplantation, the model of heterotopic intrathoracic cardiac transplantation was used. Red foxes (6–8 kg) served as donors, mongrels (15–22 kg) as recipients. Rejection was detected by cytoimmunological monitoring and endomyocardial biopsy. Mean survival time was 18.8±3.2 days (historic control 8.4± 1.9 days). Of 8 animals, 2 developed cellular rejection mechanisms (25%), 2 others developed humoral (25%) and 3 cellular and humoral (38%). One animal showed no signs of rejection. Humoral rejection episodes were not be influenced by high dosages of methylprednisolone (250 mg/day), while cellular rejections could be successfully controlled.