학술논문
Antibody-mediated targeting of TNFR2 activates CD8+T cells in mice and promotes antitumor immunity
Document Type
Article
Author
Tam, Eric M.; Fulton, Ross B.; Sampson, James F.; Muda, Marco; Camblin, Adam; Richards, Jennifer; Koshkaryev, Alexander; Tang, Jian; Kurella, Vinodh; Jiao, Yang; Xu, Lihui; Zhang, Kathy; Kohli, Neeraj; Luus, Lia; Hutto, Elizabeth; Kumar, Sandeep; Lulo, James; Paragas, Violette; Wong, Christina; Suchy, James; Grabow, Stephanie; Dugast, Anne-Sophie; Zhang, Hong; Depis, Fabien; Feau, Sonia; Jakubowski, Aniela; Qiao, Wenlian; Craig, Galina; Razlog, Maja; Qiu, James; Zhou, Yu; Marks, James D.; Croft, Michael; Drummond, Daryl C.; Raue, Andreas
Source
Science Translational Medicine; October 2019, Vol. 11 Issue: 512
Subject
Language
ISSN
19466234; 19466242
Abstract
Anti-TNFR2 antibodies induce costimulation of T cells, complete tumor regression, and immune memory in mice and can be combined with anti-PD1.