학술논문
Neonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial
Document Type
Article
Author
Schmitz, Thomas; Doret-Dion, Muriel; Sentilhes, Loic; Parant, Olivier; Claris, Olivier; Renesme, Laurent; Abbal, Julie; Girault, Aude; Torchin, Héloïse; Houllier, Marie; Le Saché, Nolwenn; Vivanti, Alexandre J; De Luca, Daniele; Winer, Norbert; Flamant, Cyril; Thuillier, Claire; Boileau, Pascal; Blanc, Julie; Brevaut, Véronique; Bouet, Pierre-Emmanuel; Gascoin, Géraldine; Beucher, Gaël; Datin-Dorriere, Valérie; Bounan, Stéphane; Bolot, Pascal; Poncelet, Christophe; Alberti, Corinne; Ursino, Moreno; Aupiais, Camille; Baud, Olivier; Boize, Philippe; Garabédian, Charles; Flamein, Florence; Le Lous, Maela; Beuchée, Alain; Gondry, Jean; Tourneux, Pierre; Coste-Mazeau, Perrine; Bedu, Antoine; Gallot, Denis; Coste, Karen; Chauleur, Céline; Patural, Hugues; Kayem, Gilles; Mitanchez, Delphine; Heckenroth, Hélène; Boubred, Farid; Sibiude, Jeanne; Desfrère, Luc; Bohec, Caroline; Mansir, Thierry; Koch, Antoine; Kuhn, Pierre; Tillouche, Nadia; Lapeyre, Fabrice; Perrotin, Franck; Favrais, Géraldine; Lecarpentier, Edouard; Durrmeyer, Xaxier; Equy, Véronique; Debillon, Thierry; Rigonnot, Luc; Lefoulgoc, Stéphanie; Brie, Claudia; Pagès, Anne-Sophie; Rayssiguier, Romy; Cambonie, Gilles; Cudeville, Corinne; Madeleneau, Doriane; Morel, Olivier; Hascoet, Jean-Michel; Letouzey, Vincent; Di Maio, Massimo; Salomon, Laurent J.; Lapillonne, Alexandre
Source
The Lancet; August 2022, Vol. 400 Issue: 10352 p592-604, 13p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Antenatal betamethasone is recommended before preterm delivery to accelerate fetal lung maturation. However, reports of growth and neurodevelopmental dose-related side-effects suggest that the current dose (12 mg plus 12 mg, 24 h apart) might be too high. We therefore investigated whether a half dose would be non-inferior to the current full dose for preventing respiratory distress syndrome.