학술논문
Effects of Oxycodone Pharmacogenetics on Postoperative Analgesia and Related Clinical Outcomes in Children: A Pilot Prospective Study
Document Type
Article
Author
Source
Pharmacogenomics; March 2023, Vol. 24 Issue: 4 p187-197, 11p
Subject
Language
ISSN
14622416; 17448042
Abstract
Background:Variability in the pharmacokinetics and pharmacodynamics of oxycodone in children undergoing surgery could be due to genetic polymorphisms. Materials & methods:The authors studied the association between clinical outcomes and pharmacogenes in children undergoing major surgery. A total of 89 children (35 undergoing pectus excavatum repair and 54 undergoing spinal fusion) were recruited. Results:OPRM1SNP rs6902403 showed an association with maximum pain score and total morphine equivalent dose (p < 0.05). Other polymorphisms in OPRM1SNP, PXR, COMTand ABCB1were also shown to be associated with average morphine equivalent dose, length of hospital stay and maximum surgical pain (p < 0.05). Conclusion:This study demonstrates novel associations between the above pharmacogenes and oxycodone’s pharmacokinetics as well as postoperative outcomes in children.Clinical trial registration: NCT03495388(ClinicalTrials.gov)