부산대학교 도서관

The aim of this study was to investigate the prognostic significance of abnormalities of cerebral oxidative phosphorylation in infants with increased echodensities. 46 newborn infants who developed increased echodensities were studied by MRS. Neurodevelopmental outcome was assessed in the survivors at 12 months of corrected age. 19 of the 27 infants with values for phosphocreatine (PCr)/inorganic orthophosphate (Pi) below 95% confidence limits for normal infants died: all 8 survivors developed disabling neurodevelopmental impairments and 7 had developmental quotients (DQ) below 80. By contrast only 2 of 19 infants with normal values for PCr/Pi died and although 10 had impairments at 12 months their disabilities were less severe and the DQ was 80 or above in 15 infants.We conclude: 1. Definite abnormalities of oxidative phosphorylation indicated severe brain damage and a very poor prognosis. 2. Some infants with apparently normal oxidative phosphorylation developed less severe brain damage which had not been detected by surface-coil MRS.