학술논문
Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial
Document Type
Article
Author
Petrylak, Daniel P; de Wit, Ronald; Chi, Kim N; Drakaki, Alexandra; Sternberg, Cora N; Nishiyama, Hiroyuki; Castellano, Daniel; Hussain, Syed; Fléchon, Aude; Bamias, Aristotelis; Yu, Evan Y; van der Heijden, Michiel S; Matsubara, Nobuaki; Alekseev, Boris; Necchi, Andrea; Géczi, Lajos; Ou, Yen-Chuan; Coskun, Hasan Senol; Su, Wen-Pin; Hegemann, Miriam; Percent, Ivor J; Lee, Jae-Lyun; Tucci, Marcello; Semenov, Andrey; Laestadius, Fredrik; Peer, Avivit; Tortora, Giampaolo; Safina, Sufia; del Muro, Xavier Garcia; Rodriguez-Vida, Alejo; Cicin, Irfan; Harputluoglu, Hakan; Widau, Ryan C; Liepa, Astra M; Walgren, Richard A; Hamid, Oday; Zimmermann, Annamaria H; Bell-McGuinn, Katherine M; Powles, Thomas; Wong, Suet-Lai Shirley; Tan, Thean Hsiang; Hovey, Elizabeth Jane; Clay, Timothy Dudley; Ng, Siobhan Su Wan; Rutten, Annemie; Machiels, Jean-Pascal; Dumez, Herlinde; Cheng, Susanna Yee-Shan; Chi, Kim Nguyen; Ferrario, Cristiano; Sengeloev, Lisa; Jensen, Niels Viggo; Thibault, Constance; Laguerre, Brigitte; Laestadius, Fredrik; Joly, Florence; Flechon, Aude; Culine, Stéphane; Becht, Catherine; Niegisch, Günter; Stöckle, Michael; Grimm, Marc-Oliver; Gakis, Georgios; Schultze-Seemann, Wolfgang; Kalofonos, Haralambos; Mavroudis, Dimitrios; Papandreou, Christos; Karavasilis, Vasilis; Bamias, Aristotelis; Révész, Janos; Geczi, Lajos; Rosenbaum, Eli; Leibowitz-Amit, Raya; Kejzman, Daniel; Peer, Avivit; Sarid, David; Scagliotti, Giorgio Vittorio; Sternberg, Cora N; Tortora, Giampaolo; Bracarda, Sergio; Necchi, Andrea; Massari, Francesco; Osawa, Takahiro; Miyajima, Naoto; Shinohara, Nobuo; Fukuta, Fumimasa; Ohyama, Chikara; Obara, Wataru; Yamashita, Shinichi; Tomita, Yoshihiko; Kawai, Koji; Fukasawa, Satoshi; Matsubara, Nobuaki; Oyama, Masafumi; Yonese, Junji; Nagata, Masayoshi; Uemura, Motohide; Nishimura, Kazuo; Kawakita, Mutsushi; Tsunemori, Hiroyuki; Hashine, Katsuyoshi; Inokuchi, Junichi; Yokomizo, Akira; Nagamori, Satoshi; Lee, Jae-Lyun; Lee, Hyo Jin; Park, Se Hoon; Rha, Sun Young; Kim, Yu Jung; Lee, Yun-Gyoo; Cortés, Leticia Vazquez; Flores, Claudia Lorena Urzua; Blaisse, Reinoud J B; van der Heijden, Michiel S; de Wit, Ronald; Erdkamp, Fransiscus L G; Aarts, Maureen J B; Wojcik-Tomaszewska, Joanna; Tomczak, Piotr; Sikora-Kupis, Bozena; Schenker, Michael; Herzal, Alina Amalia; Udrea, Anghel Adrian; Karlov, Petr; Safina, Sufia Z; Alekseev, Boris; Semenov, Andrey; Fomkin, Roman; Pulido, Enrique Grande; Del Muro, F Xavier García; Mignorance, Juan Ignacio Delgado; Gauna, Daniel Castellano; Rodríguez-Vida, Alejo; Su, Yu-Li; Ou, Yen-Chuan; Lin, Chien-Liang; Su, Wen-Pin; Lin, Chia-Chi; Yeh, Su-Peng; Çiçin, Irfan; Harputluoglu, Hakan; Erman, Mustafa; Coskun, Hasan Senol; Urun, Yuksel; Golovko, Yurii; Bondarenko, Igor; Sinielnikov, Ivan; Powles, Thomas; Crabb, Simon; Syndikus, Isabel; Huddart, Robert; Sundar, Santhanam; Chowdhury, Simon; Sarwar, Naveed; Drakaki, Alexandra; Flaig, Thomas; Pan, Chong Xian; Petrylak, Daniel; Schwarz, James; Percent, Ivor; Cultrera, Jennifer; Hainsworth, John; Herms, Benjamin; Lawler, William; Lowe, Thomas; Tagawa, Scott; Aragon-Ching, Jeanny; Vaishampayan, Ulka
Source
The Lancet; November 2017, Vol. 390 Issue: 10109 p2266-2277, 12p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Few treatments with a distinct mechanism of action are available for patients with platinum-refractory advanced or metastatic urothelial carcinoma. We assessed the efficacy and safety of treatment with docetaxel plus either ramucirumab—a human IgG1 VEGFR-2 antagonist—or placebo in this patient population.