학술논문
A large-scale genome-wide association study meta-analysis of cannabis use disorder
Document Type
Article
Author
Johnson, Emma C; Demontis, Ditte; Thorgeirsson, Thorgeir E; Walters, Raymond K; Polimanti, Renato; Hatoum, Alexander S; Sanchez-Roige, Sandra; Paul, Sarah E; Wendt, Frank R; Clarke, Toni-Kim; Lai, Dongbing; Reginsson, Gunnar W; Zhou, Hang; He, June; Baranger, David A A; Gudbjartsson, Daniel F; Wedow, Robbee; Adkins, Daniel E; Adkins, Amy E; Alexander, Jeffry; Bacanu, Silviu-Alin; Bigdeli, Tim B; Boden, Joseph; Brown, Sandra A; Bucholz, Kathleen K; Bybjerg-Grauholm, Jonas; Corley, Robin P; Degenhardt, Louisa; Dick, Danielle M; Domingue, Benjamin W; Fox, Louis; Goate, Alison M; Gordon, Scott D; Hack, Laura M; Hancock, Dana B; Hartz, Sarah M; Hickie, Ian B; Hougaard, David M; Krauter, Kenneth; Lind, Penelope A; McClintick, Jeanette N; McQueen, Matthew B; Meyers, Jacquelyn L; Montgomery, Grant W; Mors, Ole; Mortensen, Preben B; Nordentoft, Merete; Pearson, John F; Peterson, Roseann E; Reynolds, Maureen D; Rice, John P; Runarsdottir, Valgerdur; Saccone, Nancy L; Sherva, Richard; Silberg, Judy L; Tarter, Ralph E; Tyrfingsson, Thorarinn; Wall, Tamara L; Webb, Bradley T; Werge, Thomas; Wetherill, Leah; Wright, Margaret J; Zellers, Stephanie; Adams, Mark J; Bierut, Laura J; Boardman, Jason D; Copeland, William E; Farrer, Lindsay A; Foroud, Tatiana M; Gillespie, Nathan A; Grucza, Richard A; Harris, Kathleen Mullan; Heath, Andrew C; Hesselbrock, Victor; Hewitt, John K; Hopfer, Christian J; Horwood, John; Iacono, William G; Johnson, Eric O; Kendler, Kenneth S; Kennedy, Martin A; Kranzler, Henry R; Madden, Pamela A F; Maes, Hermine H; Maher, Brion S; Martin, Nicholas G; McGue, Matthew; McIntosh, Andrew M; Medland, Sarah E; Nelson, Elliot C; Porjesz, Bernice; Riley, Brien P; Stallings, Michael C; Vanyukov, Michael M; Vrieze, Scott; Walters, Raymond; Polimanti, Renato; Johnson, Emma; McClintick, Jeanette; Hatoum, Alexander; He, June; Wendt, Frank; Zhou, Hang; Adams, Mark; Adkins, Amy; Aliev, Fazil; Bacanu, Silviu-Alin; Batzler, Anthony; Bertelsen, Sarah; Biernacka, Joanna; Bigdeli, Tim; Chen, Li-Shiun; Clarke, Toni-Kim; Chou, Yi-Ling; Degenhardt, Franziska; Docherty, Anna; Edwards, Alexis; Fontanillas, Pierre; Foo, Jerome; Fox, Louis; Frank, Josef; Giegling, Ina; Gordon, Scott; Hack, Laura; Hartmann, Annette; Hartz, Sarah; Heilmann-Heimbach, Stefanie; Herms, Stefan; Hodgkinson, Colin; Hoffman, Per; Hottenga, Jouke; Kennedy, Martin; Alanne-Kinnunen, Mervi; Konte, Bettina; Lahti, Jari; Lahti-Pulkkinen, Marius; Lai, Dongbing; Ligthart, Lannie; Loukola, Anu; Maher, Brion; Mbarek, Hamdi; McIntosh, Andrew; McQueen, Matthew; Meyers, Jacquelyn; Milaneschi, Yuri; Palviainen, Teemu; Pearson, John; Peterson, Roseann; Ripatti, Samuli; Ryu, Euijung; Saccone, Nancy; Salvatore, Jessica; Sanchez-Roige, Sandra; Schwandt, Melanie; Sherva, Richard; Streit, Fabian; Strohmaier, Jana; Thomas, Nathaniel; Wang, Jen-Chyong; Webb, Bradley; Wedow, Robbee; Wetherill, Leah; Wills, Amanda; Boardman, Jason; Chen, Danfeng; Choi, Doo-Sup; Copeland, William; Culverhouse, Robert; Dahmen, Norbert; Degenhardt, Louisa; Domingue, Benjamin; Elson, Sarah; Frye, Mark; Gäbel, Wolfgang; Hayward, Caroline; Ising, Marcus; Keyes, Margaret; Kiefer, Falk; Kramer, John; Kuperman, Samuel; Lucae, Susanne; Lynskey, Michael; Maier, Wolfgang; Mann, Karl; Männistö, Satu; Müller-Myhsok, Bertram; Murray, Alison; Nurnberger, John; Palotie, Aarno; Preuss, Ulrich; Räikkönen, Katri; Reynolds, Maureen; Ridinger, Monika; Scherbaum, Norbert; Schuckit, Marc; Soyka, Michael; Treutlein, Jens; Witt, Stephanie; Wodarz, Norbert; Zill, Peter; Adkins, Daniel; Boden, Joseph; Boomsma, Dorret; Bierut, Laura; Brown, Sandra; Bucholz, Kathleen; Cichon, Sven; Costello, E. Jane; de Wit, Harriet; Diazgranados, Nancy; Dick, Danielle; Eriksson, Johan; Farrer, Lindsay; Foroud, Tatiana; Gillespie, Nathan; Goate, Alison; Goldman, David; Grucza, Richard; Hancock, Dana; Harris, Kathleen Mullan; Heath, Andrew; Hesselbrock, Victor; Hewitt, John; Hopfer, Christian; Horwood, John; Iacono, William; Johnson, Eric; Kaprio, Jaakko; Karpyak, Victor; Kendler, Kenneth; Kranzler, Henry; Krauter, Kenneth; Lichtenstein, Paul; Lind, Penelope; McGue, Matt; MacKillop, James; Madden, Pamela; Maes, Hermine; Magnusson, Patrik; Martin, Nicholas; Medland, Sarah; Montgomery, Grant; Nelson, Elliot; Nöthen, Markus; Palmer, Abraham; Pederson, Nancy; Penninx, Brenda; Porjesz, Bernice; Rice, John; Rietschel, Marcella; Riley, Brien; Rose, Richard; Rujescu, Dan; Shen, Pei-Hong; Silberg, Judy; Stallings, Michael; Tarter, Ralph; Vanyukov, Michael; Vrieze, Scott; Wall, Tamara; Whitfield, John; Zhao, Hongyu; Neale, Benjamin; Gelernter, Joel; Edenberg, Howard; Agrawal, Arpana; Davis, Lea K; Bogdan, Ryan; Gelernter, Joel; Edenberg, Howard J; Stefansson, Kari; Børglum, Anders D; Agrawal, Arpana
Source
The Lancet Psychiatry; December 2020, Vol. 7 Issue: 12 p1032-1045, 14p
Subject
Language
ISSN
22150366
Abstract
Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50–70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder.