학술논문
ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation
Document Type
Article
Author
Source
Genes & Development; 2021, Vol. 35 p1142-1160, 19p
Subject
Language
ISSN
08909369; 15495477
Abstract
Here, Urrutia et al. set out to study the mechanism that regulates the choice between pluripotency and differentiation in embryonic stem cells (ESCs). Using biochemical and genomic analyses, the authors identify SUMO2 modification of Satb2 by the E3 ligase Zfp451 as a driver of ESC differentiation.