학술논문
H2A.Z chaperones converge on E2F target genes for melanoma cell proliferation
Document Type
Article
Author
Source
Genes & Development; 2024, Vol. 38 Issue: 7-8 p336-353, 18p
Subject
Language
ISSN
08909369; 15495477
Abstract
In this study, Jostes et al. describe the essential role for H2A.Z histone chaperones SCRAP, p400, and YL1 in regulating H2A.Z deposition and H4 acetylation on chromatin in melanoma cells. Their findings demonstrate that the chaperones coordinate expression of E2F1 and its targets, thereby highlighting a new epigenetic strategy for cancer intervention.