학술논문
Transient prehypertensive treatment in spontaneously hypertensive rats a comparison of spironolactone and losartan regarding long-term blood pressure and target organ damage
Document Type
Article
Author
Source
Journal of Hypertension; December 2007, Vol. 25 Issue: 12 p2504-2511, 8p
Subject
Language
ISSN
02636352; 14735598
Abstract
We previously demonstrated that when the renin–angiotensin system (RAS) is transiently blocked by an angiotensin receptor blocker (ARB) in young spontaneously hypertensive rats (SHR), this results in a prolonged blood pressure decrease and protection against target organ damage. Aldosterone is an essential hormone in the RAS, and contributes to pathologic remodeling. Thus, part of the protective effects of the ARB may be due to inhibition of aldosterone-mediated effects. To test this hypothesis, in young SHR, we compared the effectiveness of transient treatment with the mineralocorticoid receptor blocker spironolactone with those obtained by the ARB losartan.