학술논문
Isolation of Mycobacterium tuberculosis Strains with a Silent Mutation in rpoB Leading to Potential Misassignment of Resistance Category
Document Type
Article
Author
Source
Journal of Clinical Microbiology; July 2011, Vol. 49 Issue: 7 p2688-2690, 3p
Subject
Language
ISSN
00951137; 1098660X
Abstract
Our study provides an alert regarding the transmission of rifampin-susceptible strains of Mycobacterium tuberculosis with a silent substitution in codon 514 of rpoB. Among 1,450 cases, we identified 12 isolates sharing this mutation and related restriction fragment length polymorphism (RFLP) types. The mutation impaired hybridization with the wild-type probes in three independent commercial assays, which could lead to misassignment of resistance.