학술논문
Pharmacogenomics variants are associated with BMI differences between individuals with bipolar and other psychiatric disorders
Document Type
Article
Author
Source
Pharmacogenomics; August 2021, Vol. 22 Issue: 12 p749-760, 12p
Subject
Language
ISSN
14622416; 17448042
Abstract
Aim:Regardless of the plethora of next-generation sequencing studies in the field of pharmacogenomics (PGx), the potential effect of covariate variables on PGx response within deeply phenotyped cohorts remains unexplored. Materials & methods:We explored with advanced statistical methods the potential influence of BMI, as a covariate variable, on PGx response in a Greek cohort with psychiatric disorders. Results:Nine PGx variants within UGT1A6, SLC22A4, GSTP1, CYP4B1, CES1, SLC29A3and DPYDwere associated with altered BMI in different psychiatric disorder groups. Carriers of rs2070959 (UGT1A6), rs199861210 (SLC29A3) and rs2297595 (DPYD) were also characterized by significant changes in the mean BMI, depending on the presence of psychiatric disorders. Conclusion:Specific PGx variants are significantly associated with BMI in a Greek cohort with psychiatric disorders.